Peer-reviewed journal publications
  1. I.M.M. van Leeuwen, G.R. Mirams, A. Walter, A.G. Fletcher, P. Murray, J. Osborne, S. Varma, S.J. Young, J. Cooper, J. Pitt-Francis, L. Momtahan, P. Pathmanathan, J.P. Whiteley, S.J. Chapman, D.J. Gavaghan, O.E. Jensen, J.R. King, P.K. Maini, S.L. Waters and H.M. Byrne (2009). An integrative computational model for intestinal tissue renewal. Cell Prolif. 42:617-636. [pdf]
  2. J. Pitt-Francis, P. Pathmanathan, M.O. Bernabeu, R. Bordas, J. Cooper, A.G. Fletcher, G.R. Mirams, P. Murray, J.M. Osborne, A. Walter, J. Chapman, A. Garny, I.M.M. van Leeuwen, P.K. Maini, B. Rodriguez, S.L. Waters, J.P. Whiteley, H.M. Byrne and D.J. Gavaghan (2009). Chaste: a test-driven approach to software development for biological modelling. Comput. Phys. Comm., 180:2452-2471. [pdf]
  3. P. Pathmanathan, J. Cooper, A.G. Fletcher, G.R. Mirams, L. Momtahan, P. Murray, J. Osborne, J. Pitt-Francis, A. Walter and S.J. Chapman (2009). A computational study of discrete mechanical tissue models. Phys. Biol., 6:036001. [pdf]
  4. J.M. Osborne, A. Walter, S.K. Kershaw, G.R. Mirams, A.G. Fletcher, P. Pathmanathan, D.J. Gavaghan, O.E. Jensen, P.K. Maini and H.M. Byrne (2010). A hybrid approach to multiscale modelling of cancer. Phil. Trans. R. Soc. A 368:5013-5028. [pdf]
  5. P. Murray, A. Walter, A.G. Fletcher, C. Edwards, M. Tindall and P.K. Maini (2011). Comparing a discrete and continuum model of the intestinal crypt. Phys. Biol. 8:026011. [pdf]
  6. S.-J. Dunn, A.G. Fletcher, S.J. Chapman, D.J. Gavaghan and J.M. Osborne (2012). Modelling the role of the basement membrane beneath a growing epithelial monolayer. J. Theor. Biol. 298:82-91. [pdf]
  7. A.G. Fletcher, C.J. Breward and S.J. Chapman (2012). Mathematical modelling of monoclonal conversion in the colonic crypt. J. Theor. Biol. 300:118-133. [pdf]
  8. R. Dello Ioio, C. Galinha, A.G. Fletcher, S.P. Grigg, A. Molnar, S. Sabatini, D. Baulcombe, P.K. Maini and M. Tsiantis (2012). A PHABULOSA/cytokinin feedback loop controls root growth in Arabidopsis. Curr. Biol. 22:1699-1704. [pdf]
  9. G.R. Mirams, A.G. Fletcher*, P.K. Maini and H.M. Byrne (2012). A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt. J. Theor. Biol. 312:143-156. *Joint first author. [pdf]
  10. G.R. Mirams, C.J. Arthurs, M.O. Bernabeu, R. Bordas, J. Cooper, A. Corrias, Y. Davit, S-J. Dunn, A.G. Fletcher, D.G. Harvey, M.E. Marsh, J.M. Osborne, P. Pathmanathan, J. Pitt-Francis, J. Southern, N. Zemzemi and D.J. Gavaghan (2013). Chaste: an open source C++ library for computational physiology and biology. PLoS Comput. Biol. 9:e1002970. [pdf]
  11. B. Lloyd-Lewis, A.G. Fletcher, T.C. Dale and H.M. Byrne (2013). Towards a quantitative understanding of the Wnt/β-catenin pathway through simulation and experiment. WIREs Syst. Biol. Med. 5:391-407. *Joint first author. [pdf]
  12. G. Rosser, A.G. Fletcher, P.K. Maini and R.E. Baker (2013). The effect of sampling rate on observed statistics in a correlated random walk. J. R. Soc. Interface 10:20130273. [pdf]
  13. J.-P. Vincent, A.G. Fletcher and L.A. Baena-Lopez (2013). Mechanisms and mechanics of cell competition in epithelia. Nat. Rev. Mol. Cell Biol. 14:581-591. [pdf]
  14. G. Rosser, A.G. Fletcher, D.A. Wilkinson, J.A. de Beyer, C.A. Yates, J.P. Armitage, P.K. Maini and R.E. Baker (2013). Novel methods for analysing bacterial tracks reveal persistence in Rhodobacter sphaeroides. PLoS Comput. Biol. 9(10):e1003276. [pdf]
  15. K. Bloch, H. Smith, V. van Hamel Parsons, D. Gavaghan, C. Kelly, A.G. Fletcher, P.K. Maini and R. Callaghan (2014). Metabolic alterations during the growth of tumour spheroids. Cell Biochem. Biophys. [pdf]
  16. A.G. Fletcher, J.M. Osborne, P.K. Maini and D.J. Gavaghan (2013). Implementing vertex dynamics models of cell populations in biology within a consistent computational framework. Prog. Biophys. Mol. Biol. 113(2):299-326. [pdf]
  17. A.G. Fletcher, M. Osterfield, R.E. Baker and S. Shvartsman (2014). Vertex models of epithelial morphogenesis. Biophys. J. 106:2291-2304. [pdf]
  18. J.M. Osborne, M.O. Bernabeu, M. Bruna, B. Calderhead, J. Cooper, N. Dalchau, S.-J. Dunn, A.G. Fletcher, R. Freeman, D. Groen, B. Knapp, G.J. McInerny, G.R. Mirams, J. Pitt-Francis, B. Sengupta, D.W. Wright, C.A. Yates, D.J. Gavaghan, S. Emmott and C. Deane (2014). Ten simple rules for effective computational research. PLOS Comput. Biol. 10(3):e1003506. [pdf]
  19. G. Rosser, R.E. Baker, J.P. Armitage and A.G. Fletcher (2014). Modelling and analysis of bacterial tracks suggest an active reorientation mechanism in Rhodobacter sphaeroides. J. R. Soc. Interface 11(97):20140320. [pdf]
  20. A.-M. Baker, B. Cereser, S. Melton, A.G. Fletcher, M. Rodriguez-Justo, P.J. Tadrous, A. Humphries, G. Elia, S.A.C. McDonald, N.A. Wright, B.D. Simons, M. Jansen and T.A. Graham (2014). Quantification of crypt and stem cell evolution in the normal and neoplastic human colon. Cell Rep. 8:940-947. [pdf]
  21. D.R. Grimes, A.G. Fletcher and M. Partridge (2014). Oxygen consumption dynamics in steady-state tumour models. R. Soc. Open Sci. 1:140080. [pdf]
  22. J.G. Scott, A.G. Fletcher, P.K. Maini, A.R.A. Anderson and P. Gerlee (2013). A filter-flow perspective of hematogenous metastasis offers a non-genetic paradigm for personalized cancer therapy. Eur. J. Cancer 50:3068-3075 [pdf]
  23. B. Knapp, R. Bardenet, M. Bernabeu, R. Bordas, M. Bruna, B. Calderhead, J. Cooper, A. Fletcher, D. Groen, B. Kuijper, J. Lewis, G. McInerny, T. Missen, J. Osborne, V. Paulitschke, J. Pitt-Francis, J. Todoric, C. Yates, D. Gavaghan, C. Deane (2014). Ten simple rules for a successful cross-disciplinary collaboration. PLoS Comput. Biol. 11:e1004214. [pdf]
  24. D. Harvey, A. Fletcher, J. Osborne, J. Pitt-Francis (2015). A parallel implementation of an off-lattice individual-based model of multicellular populations. Comput. Phys. Commun. 192:130-137 [pdf]
  25. A. Fletcher, P. Murray, P. Maini (2015). Multiscale modelling of intestinal crypt organization and carcinogenesis. Math. Mod. Meth. Appl. Sci. 25:2563-2585 [pdf]
  26. O. Maclaren, H. Byrne, A. Fletcher, P. Maini (2015). Models, measurement and inference in epithelial tissue dynamics. Math. Biosci. Eng. 12:1321-1340 [pdf]
  27. C. Narciso, P. Brodskiy, G. Garston, R. Baker, A. Fletcher, J. Zartman (2015). Patterning of wound-induced intercellular Ca2+ flashes in a developing epithelium. Phys. Biol. 12:056005
  28. D. Nichol, P. Jeavons, A. Fletcher, R. Bonomo, P. Maini, J. Paul, R. Gatenby, A. Anderson, J. Scott (2015). Steering evolution with combination therapy to prevent the emergence of bacterial antibiotic resistance. PLOS Comput. Biol. 11:e1004493 [pdf]
  29. R. Niehus, S. Mitri, A. Fletcher, K. Foster (2015). Migration and horizontal gene transfer divide microbial genomes into multiple niches. Nat. Commun. 6:8924 [pdf]
  30. J. Kursawe, P. Brodskiy, J. Zartman, R. Baker, A. Fletcher (2015). Capabilities and limitations of tissue size control through passive mechanical forces. PLOS Comput. Biol. In press. [pdf]
  31. J. Scott, A. Fletcher, A. Anderson, P. Maini (2016). Spatial metrics of tumour vascular organisation predict radiation efficacy in a computational model. PLOS Comput. Biol. In press. [pdf]
  32. A. Dhawan, T. Graham, A. Fletcher (2016). A computational modelling approach for deriving biomarkers to predict cancer risk in premalignant disease. Cancer Prev. Res. Accepted. [pdf]
Peer-reviewed book chapters
  1. A.G. Fletcher, G.R. Mirams, P.J. Murray, A. Walter, J.-W. Kang, K.-H. Cho, P.K. Maini and H.M. Byrne (2010). Multiscale modeling of colonic crypts and early colorectal cancer. In Multiscale Cancer Modeling, Editor: TS Deisboeck, ISBN: 9781439814406. [pdf]
  2. J.G. Scott, P. Gerlee, D. Basanta, A.G. Fletcher, P.K. Maini and A.R.A. Anderson (2013). Mathematical modeling of the metastatic process. In Experimental metastasis: Modelling and Analysis, Springer Science. In press. [pdf]
Study group reports
  1. A.G. Fletcher, G.R. Mirams, J. Rougier, I. Shvartsman and A/ Walter (2006). Bacterial proteins that knock out cell defences: cruise missiles or cannonballs? Proceedings of the 5th Mathematics in Medicine Study Group. [pdf]
  2. C. Breward, S. Eastburn, A.G. Fletcher, J. King, M. Mather and A. Walter (2007). Identification of point of passage for cell culture. Proceedings of the 6th Mathematics in Medicine Study Group. [pdf]
  1. A.G. Fletcher. Aspects of tumour modelling from the subcellular to the tissue scale. DPhil thesis (2010)
  2. A.G. Fletcher. Modelling transport processes in spinal discs. MSc thesis (2004)